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pentobarbital will reduce the extent or outcome of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Effect of coadministering a strong CYP3A4 inducer with fedratinib has not been studied.pentobarbital will decrease the level or impact of tadalafil by impacting hepatic/intestinal enzyme CYP